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Primary Central Nervous System Vasculitis

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CNS vasculitis exists in medium- and large-vessel, small-vessel, and amyloid-deposition forms. Diagnosis is difficult, but the typical symptoms include acute focal deficits, cognitive impairment, and headache.

​   The New England Journal of Medicine: Search Results in Neurology/Neurosurgery

Nestor Maslej: «Mucha gente es más consciente del progreso de la IA, y también está más nerviosa»

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WIRED Summit 2024 recibe a Nestor Maslej, director de investigación en el Instituto de Inteligencia Artificial Centrada en el Humano, quien nos habla del “Índice de IA”, un análisis enfocado en el rastreo del avance de la IA.

​WIRED Summit 2024 recibe a Nestor Maslej, director de investigación en el Instituto de Inteligencia Artificial Centrada en el Humano, quien nos habla del “Índice de IA”, un análisis enfocado en el rastreo del avance de la IA.   Noticias sobre negocios

Axatilimab in Recurrent or Refractory Chronic Graft-versus-Host Disease

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A study in patients with chronic GVHD evaluated three doses of axatilimab, a colony-stimulating factor 1 receptor antibody. The lowest dose appeared to maximize response with the fewest adverse effects.

​   The New England Journal of Medicine: Search Results in Hematology/Oncology

Flail Chest

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A 59-year-old man was brought to the emergency department after a motor vehicle collision. Paradoxical movement of a segment of his chest wall during respiration was noted on examination (shown in a video).

​   The New England Journal of Medicine: Search Results in Pulmonary/Critical Care

Case 29-2024: A 47-Year-Old Man with Confusion and Kidney Failure

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A 47-year-old man was admitted to the hospital because of confusion, pneumonia involving the right lower lobe, and acute kidney failure. The creatine kinase level was 28,581 U per liter. A diagnosis was made.

​   The New England Journal of Medicine: Search Results in Pulmonary/Critical Care

Fabry’s Disease

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A 44-year-old man presented with a 5-year history of heat intolerance and burning pain in his hands and feet. He had periumbilical angiokeratomas and nonnephrotic proteinuria. A kidney biopsy was performed.

​   The New England Journal of Medicine: Search Results in Dermatology

Science behind the Study: CSF1R Blockade for Refractory Chronic Graft-versus-Host Disease

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This editorial describes the science behind a study of axatilimab to treat chronic graft-versus-host disease.

​   The New England Journal of Medicine: Search Results in Hematology/Oncology

Targeting CSF1R in Chronic GVHD — Lessons in Translation

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Chronic graft-versus-host disease (GVHD) remains a rare and unacceptably debilitating autoimmune-like syndrome that afflicts patients in whom a blood disorder or cancer is otherwise cured by means of allogeneic hematopoietic stem-cell transplantation (HSCT). After allogeneic HSCT is performed, ongoing loss of T-cell and B-cell immune tolerance occurs as a new…

​   The New England Journal of Medicine: Search Results in Hematology/Oncology

Pomalidomide for Epistaxis in Hereditary Hemorrhagic Telangiectasia

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Patients with HHT received pomalidomide or placebo for 24 weeks. Pomalidomide reduced epistaxis frequency and severity.

​   The New England Journal of Medicine: Search Results in Hematology/Oncology

Bending the Overdose Curve — Still Not Enough

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The multiple waves of overdose deaths in the United States continue to morph in new and unexpected directions, now driven by fentanyl used in combination with other substances.1 Despite our public health policies and clinical efforts to drive the curve downward, we have achieved only a slight reduction…

​   The New England Journal of Medicine: Search Results in Pediatrics