Amyloidosis, a systemic disease that manifests in various ways, should be in the differential diagnosis of unexplained proteinuria, restrictive cardiomyopathy, peripheral and autonomic neuropathy, and hepatomegaly. Treatments are improving.

​   The New England Journal of Medicine: Search Results in Neurology/Neurosurgery

A 78-year-old man presented with a 5-day history of constipation and flank bulge. Eight days before presentation, he had received a diagnosis of herpes zoster of the left flank.

​   The New England Journal of Medicine: Search Results in Neurology/Neurosurgery

In a randomized, placebo-controlled trial involving patients 12 to 65 years of age with eosinophilic esophagitis, benralizumab reduced esophageal eosinophil counts but did not reduce dysphagia symptoms.

​   The New England Journal of Medicine: Search Results in Allergy/Immunology

Eosinophilic esophagitis is a chronic, allergic disease associated with type 2 helper T cell (Th2) inflammation that has increased rapidly in incidence and prevalence.1 Symptoms of eosinophilic esophagitis vary according to age. Adults frequently present with dysphagia and food impactions, whereas young children may present with vomiting, abdominal…

​   The New England Journal of Medicine: Search Results in Allergy/Immunology

Dupilumab, a human monoclonal antibody that blocks interleukin-4 and interleukin-13 pathways, led to histologic remission in a significantly higher percentage of children with eosinophilic esophagitis than placebo.

​   The New England Journal of Medicine: Search Results in Allergy/Immunology

A 73-year-old man was admitted because of 22 months of recurrent fever and progressive hypodensities in the liver. A liver-biopsy specimen showed nonnecrotizing granulomas. A diagnosis was made.

​   The New England Journal of Medicine: Search Results in Allergy/Immunology