Response and Resistance to Menin Inhibitor in UBTF–Tandem Duplication AML

Tandem duplication in UBTF is associated with a resistant form of AML. A menin inhibitor induced a short-lived response. Resistance was associated with mutations at the drug-binding site in MEN1, which encodes menin 1.

​   The New England Journal of Medicine: Search Results in Hematology/Oncology