Neoadjuvant Treatment of Mismatch Repair–Deficient Colon Cancer — Clinically Meaningful?

In this issue of the Journal, Chalabi and colleagues1 present findings from a large study showing impressive pathological responses of mismatch repair–deficient (dMMR) early-stage colon cancers to neoadjuvant dual immune checkpoint blockade followed by surgical resection. This study was started as a proof-of-principle pilot study with…

​   The New England Journal of Medicine: Search Results in Gastroenterology