Interleukin-23 p19 and Interleukin-12 p40, Head-to-Head, against Gut Inflammation

The interleukin-12 and interleukin-23 cytokines play a critical role in homeostasis and inflammation in the intestine and share various features, including a common p40 cytokine subunit, a common interleukin-12Rβ1 receptor subunit, and Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling molecules that communicate downstream functions1,2 (

​   The New England Journal of Medicine: Search Results in Allergy/Immunology