Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer
In PIK3CA-mutated, HR-positive, HER2-negative locally advanced or metastatic breast cancer, inavolisib plus palbociclib–fulvestrant led to significantly longer progression-free survival than placebo plus palbociclib–fulvestrant.
The New...
The Way to a Patient’s Heart — Vascular Access in Cardiac Arrest
Every year, thousands of lives are saved with cardiopulmonary resuscitation (CPR). Yet, overall survival among patients with out-of-hospital cardiac arrest is approximately 10%, even...
Glucagon-Like Peptide-1 Receptor Agonists and Osteoarthritis
Osteoarthritis is one of the world’s leading causes of disability. Roughly 4.3% of adults have painful knee osteoarthritis, with knee pain on most days1...
Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis
Among participants with obesity and pain related to knee osteoarthritis, treatment with weekly semaglutide for 68 weeks resulted in greater reductions in body weight...
Watchful Waiting versus Antibiotics for Acute Otitis Media in Pediatric Patients
This case vignette of a 13-month-old girl with fever and acute otitis media in one ear is accompanied by two essays, one recommending watchful...
