Science behind the Study: Combination Therapy for Chronic HBV Infection
The authors describe the science behind a clinical trial of a combination of therapies, including xalnesiran, to treat chronic hepatitis B virus infection.
The New...
Case 38-2024: A 22-Year-Old Woman with Headache, Fever, and Respiratory Failure
A 22-year-old woman with headache and fever was transferred to the ICU for respiratory failure. Head CT was notable for acute subarachnoid hemorrhage; transthoracic...
Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B
In a phase 2 trial involving participants taking a nucleoside or nucleotide analogue, 23% of those assigned to receive xalnesiran plus pegylated interferon alfa-2a...
Heating Up IDH-Mutant Gliomas
A recent study unpicks a key immune-mediated mechanism of mutant IDH–blocking drugs such as vorasidenib in the treatment of IDH-mutant glioma.
The New England Journal...
Sepsis and Septic Shock
Sepsis is a life-threatening, heterogeneous disorder involving a dysregulated immune response to infection. Research to identify subtypes and targeted therapies for host dysregulation is...
