Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage
In a trial involving patients with subarachnoid hemorrhage and anemia, liberal transfusion of red cells did not result in a lower risk of an...
Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A
Five patients with hemophilia A had dramatic reductions in bleeding episodes after undergoing autologous HSCT with lentiviral vector–transduced cells encoding a CD68-targeted factor VIII...
Long-Acting HIV Medicines and the Pandemic Inequality Cycle — Rethinking Access
A new era of long-acting antiretrovirals for HIV treatment and prevention demands a nonlinear approach to global access with faster sharing of technology, decentralized...
Could Lentivirus Overcome the AAV Gene-Therapy Challenges in Hemophilia A?
Despite the unprecedented evolution of new replacement and nonreplacement therapies, many unmet needs remain with respect to the treatment of severe hemophilia A.1 These...
Daratumumab or Active Monitoring for High-Risk Smoldering Multiple Myeloma
Among patients with smoldering multiple myeloma at high risk for progression, progression-free survival at 5 years was 63.1% with daratumumab monotherapy, as compared with...
