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Science behind the Study: JAK Inhibition Immunotherapy for APS-1

This editorial describes the science behind a study of the mechanism and treatment of autoimmune polyendocrine syndrome type 1 (also known as APECED), which...

Thirst, Hunger, and Nephrogenic Diabetes Insipidus

“Buridan’s ass” refers to a philosophical conundrum about free will. If a person is equally hungry and thirsty, which urge is satisfied first? A...

Case 16-2024: A 20-Year-Old Man with a Pustular Rash

A 20-year-old man was evaluated for a pustular rash that had progressed over a period of several days. The lesions were at various stages...

The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1

In this study, interferon-γ was found to play a large role in the pathogenesis of APS-1. Results were confirmed in studies in animals and...

AI in Medicine: Medical Artificial Intelligence and Human Values

In this article in the series on artificial intelligence in medicine, the authors explore how human values influence the outputs of large language models...

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