Success in Sight for Gene Editing
The development of efficient new gene-editing techniques has improved the prospect of curative genetic medicines. In 2012, Jinek and colleagues described an adaptive immune...
Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair–Deficient Colon Cancer
Neoadjuvant nivolumab plus ipilimumab results in a substantial pathological response in most patients with mismatch repair–deficient colon cancer and appears to be safe.
The New...
Neoadjuvant Treatment of Mismatch Repair–Deficient Colon Cancer — Clinically Meaningful?
In this issue of the Journal, Chalabi and colleagues1 present findings from a large study showing impressive pathological responses of mismatch repair–deficient (dMMR) early-stage...
Genome Sequencing for Diagnosing Rare Diseases
Genetic diagnosis of rare diseases is made through a variety of methods. This study gauged the diagnostic yield of genome sequencing after negative results...
Neoadjuvant Treatment of Mismatch Repair–Deficient Colon Cancer — Clinically Meaningful?
In this issue of the Journal, Chalabi and colleagues1 present findings from a large study showing impressive pathological responses of mismatch repair–deficient (dMMR) early-stage...
