Combination Targeted Therapy in Relapsed Diffuse Large B-Cell Lymphoma
In a phase 1b–2 study, a five-agent treatment aimed at tumor survival pathways in relapsed and refractory diffuse large B-cell lymphoma was associated with...
Protection against Alzheimer’s Disease with APOE Christchurch Variant — How?
Protective variants of genetic loci are of particular interest for two reasons: first, because they are important from a clinical genetic perspective; and second,...
Insulin-Induced Lipohypertrophy
A 65-year-old man with type 2 diabetes presented to the hospital with hyperosmolar hyperglycemic state. He had rubbery, subcutaneous masses near the umbilicus at...
Congenital and Acquired Chiari Syndrome
Symptomatic CM1, also called the Chiari syndrome, is characterized mainly by headache but also by numbness or weakness in the hands or feet and...
APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease
In a kindred with PSEN1E280A, which causes autosomal dominant Alzheimer’s disease, heterozygosity for the APOE3 Christchurch variant was associated with delayed onset of symptoms.
The...
