Phase 1 Trials of PNPLA3 siRNA in I148M Homozygous Patients with MAFLD
Homozygosity for the PNPLA3 risk allele is linked to liver fat accumulation. In phase 1 trials, JNJ-75220795, a hepatocyte-targeted GalNAc-conjugated PNPLA3 siRNA, reduced liver...
Intrathoracic Migration of a Breast Implant
A 73-year-old woman with a history of breast-implant surgery and segmental lung resection had sudden displacement of her right breast implant during pulmonary-function testing.
The...
Race-Based Screening under the Public Health Ethics Microscope — The Case of Prostate Cancer
Principles of public health ethics suggest that committees developing prostate cancer–screening guidelines should thoroughly examine the scientific rationale and social impact of using race-based...
Chilblain Lupus Erythematosus
A 29-year-old woman with a history of systemic lupus erythematosus presented to the dermatology clinic with a 2-week history of a rash on her...
A Legacy of Cruelty to Sexual and Gender Minority Groups
New England Journal of Medicine, Ahead of Print.
massmed: New England Journal of Medicine: Table of Contents
